| Record no |
201102179012 |
| Activity status |
Dead or Administration by others |
| Working Title |
PREPARATION OF L-SUBSTITUTED AMINO-L-SUBSTITUTED THIO-2-NITRO ALKENES |
| Working Inventors |
ABDUL R;DESHMUKH;BHAWAL;SHIRALKAR;RAJAPPA; |
| Contributing institutions |
NCL |
| Administered by |
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| Ownership |
|
| Categories > Subjects |
Organic chemistry |
| Categories > Portfolio |
Petrochemicals/industrial chemicals |
| Disclosure number |
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| NCL No |
1988-NCL-0005 |
| CSIR No |
1988-NF-0135
|
| Priority date |
01-03-1989 |
| Country |
US |
| Application number |
353388 |
| Provisional filing date |
|
| Complete filing date |
05-16-1989 |
| Publication status |
Yes |
| Publication date |
10-30-1990 |
| Publication no |
US19890353388 |
| Granted number |
4967007 |
| Granted date |
10-30-1990 |
| Final title |
PREPARATION OF L-SUBSTITUTED AMINO-L-SUBSTITUTED THIO-2-NITRO ALKENES |
| Final Inventors |
ABDUL R;DESHMUKH;BHAWAL B;SHIRALKAR V;RAJAPPA S; |
| Abstract |
A process is disclosed for the manufacture of 1 substituted amino 1 substituted thio 2 nitro alkenes of the general formula. R1NH R2S C CR3 NO2 may consist of hydrogen alkyl aryl or arylalkyl groups or combinations thereof. These alkenes are prepared by reacting a primary amine with a compound of sulfur in tne presence of a primary catalyst to obtain a carbonimidodithioic acid salt which is converted to a corresponding ester whtch is thereafter reacted with a nitrocompound in the presence of a secondary catalyst.1 methylamino l methylthio 2 nitroethene is an important intermediate in the synthesis of Rantitidine and Nizatidine which are used as effective drugs in the treatment of peptic ulcers and associated gastrointestinal
disorders. |
| Case status |
Granted + Allowed to lapse |
| Licensing status |
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| Licensing case no |
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| Client name |
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| Lead inventors |
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| Categories > Industry > Primary |
Petrochemicals |
| Categories > Industry > other |
|