| Record no |
201103081859 |
| Activity status |
Dead or Administration by others |
| Working Title |
AN IMPROVED PROCESS FOR THE PREPARATION OF 1-SUBSTITUTED AMINO-1-SUBSTITUTED THIO-2-NITRO ALKENES |
| Working Inventors |
DESHMUKH, ABDUL RAKEEB ABDUL SUBHAN;BHAWAL, BABURAO MANIKRAO;SHIRALKAR, VASUDEO PANDURANG;RAJAPPA, SRINIVASACHARI; |
| Contributing institutions |
NCL |
| Administered by |
|
| Ownership |
|
| Categories > Subjects |
Organic chemistry |
| Categories > Portfolio |
Petrochemicals/industrial chemicals |
| Disclosure number |
|
| NCL No |
1988-NCL-0005 |
| CSIR No |
1988-NF-0135
|
| Priority date |
05-10-1989 |
| Country |
EP |
| Application number |
89304707.6 |
| Provisional filing date |
|
| Complete filing date |
05-10-1989 |
| Publication status |
Yes |
| Publication date |
11-14-1990 |
| Publication no |
EP0396830 A1 |
| Granted number |
0396830 |
| Granted date |
10-27-1993 |
| Final title |
AN IMPROVED PROCESS FOR THE PREPARATION OF 1-SUBSTITUTED AMINO-1-SUBSTITUTED THIO-2-NITRO ALKENES |
| Final Inventors |
DESHMUKH, ABDUL RAKEEB ABDUL SUBHAN;BHAWAL, BABURAO MANIKRAO;SHIRALKAR, VASUDEO PANDURANG;RAJAPPA, SRINIVASACHARI; |
| Abstract |
A process is disclosed for the manufacture of 1 substituted amino 1 substituted thio 2 nitro alkenes of the general formula R1 NH R2S C CR3 NO2 wherein R1 R2 R3 may be the same or different and may consist of hydrogen alkyl aryl arylalkyl groups or combinations thereof. These alkenes are prepared by reacting a primary amine with a compound of sulfur in the presence of a primary catalyst to obtain a carbonimidodithioic acid salt which is converted to a corresponding ester which is thereafter reacted with a nitro compound in the presence of a secondary catalyst. 1 methylamino 1 methylthio 2 nitroethene is an important intermediate in the synthesis of Rantitidine and Nizatidine which are antiulcer drugs and associated gastrointestinal disorders. |
| Case status |
Granted + Allowed to lapse |
| Licensing status |
|
| Licensing case no |
|
| Client name |
|
| Lead inventors |
|
| Categories > Industry > Primary |
Feedstocks and Organic Chemicals |
| Categories > Industry > other |
|