Knowhow offering
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| Title | Process for Preparation of Copolymer-1-used in the treatment of multiple sclerosis |
| Knowhow is available for | Process for synthesis of CoPolymer1 and its pharmaceutically acceptable salts |
| Summary | A novel process using readily available raw materials, for the synthesis of Copolymer-1 and its pharmaceutically acceptable salts is described here. The process uses a polymer bound catalyst as an initiator (which requires 10X less catalyst concentration than conventional systems). The resulting polymer has a narrow molecular weight distribution, with m.wt can be tailored to be in the range of 8-19KDa. Copolymer-1 could be injected subcutaneously, intra-peritoneally, intravenously, intramuscularly for the treatment of multiple sclerosis. |
| Advantages | • A simple, cost-effective process using easily available raw materials
• Yields a product with high degree of purity (without requiring additional steps of separation, purification etc.)
• Molecular weight can be tailored to be in the range of 8-19KDa (hence overcoming toxicity issues; m. wt of over 20 KDa are known to be toxic)- with excellent control over the m. wt distribution
• High purity levels - almost no acid residues (less than 1% )
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Knowhow is listed under following categories
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Knowhow from
| CSIR-NCL, Pune |
| Scientific/ engineering subject areas |
Chemical sciences & engineering ; Others |
| Investor interest categories |
Materials Technology including Nanotechnology ; Biotechnology/ Biomedical/ Health Technologies |
| Industries |
Pharmaceuticals, Bulk Drugs, Formulations ; |