Knowhow offering
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| Title | A library of new small molecules that could be used as anticancer, antiviral drugs |
| Knowhow is available for | A synthetic routine that allows one to manipulate the substrate flexibility at the final/penultimate steps- yielding a small library of modified nucleosides without the need for synthesising every compound from the beginning, and hence siginificantly reducing drug development time and costs. |
| Summary | NCL’s technology provides a strategy that allows synthesizing spironucleosides with enormous flexibility to modulate the substituents and properties of the resulting compounds at the final/penultimate steps. The provision to manipulate the substrate flexibility allows this approach to yield a small library of modified nucleosides without synthesizing every compound from the beginning. |
| Advantages | • Cycloaddition process used is of high synthetic efficiency
• These libraries significantly reduce drug development time and efforts
• Good yield in the presence of the recommended catalysts
• Easy and flexible penultimate bicycloannulation step involved
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Knowhow is listed under following categories
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Knowhow from
| CSIR-NCL, Pune |
| Scientific/ engineering subject areas |
Chemical sciences & engineering ; Life sciences/ biosciences & engineering |
| Investor interest categories |
Materials Technology including Nanotechnology ; Biotechnology/ Biomedical/ Health Technologies |
| Industries |
Pharmaceuticals, Bulk Drugs, Formulations ; |